Momenta Pharmaceuticals Announces Presentations at the American Association for Cancer Research (AACR) Annual Meeting 2019
“Therapeutics like Rituxan® and Darzalex®, which engage the Fc gamma receptor and complement systems to mediate cell depletion, are important standards-of-care for patients with cancer and autoimmune disease. However, inefficent engagement limits efficacy and, in many patients, contributes to drug resistance,” said
|Title: Discovery of a Potential Best-in-Class Anti-CD38 Therapeutic Utilizing Fc Multimerization(Session PO.IM02.16 – Therapeutic Antibodies 1, Abstract 561/25)
Date: March 31, 2019
Time: 1:00 pm-5:00 pm ET
Location: Section 23, Georgia World Conference Center, Atlanta
Anti-CD38 monoclonal antibodies (mAbs) induce tumor cell depletion in part by Fc-dependent effector mechanisms. This presentation describes the discovery of a novel anti-CD38 Fc multimer with superior efficacy and potency to existing anti-CD38 therapeutic antibodies in both cell systems and in non-human primates, and also with the ability to efficiently deplete Darzalex-resistant multiple myeloma patient tumor cells.
|Title: Improved Fc-mediated Effector Functions By An Anti-CTLA-4 Multivalent Fc Agent
(Session PO.IM02.05 – Immune Checkpoints 1, Abstract 3244 / 24)
Date: April 2, 2019
Time: 8:00 am -12:00 pm ET
Location: Section 24, Georgia World Conference Center, Atlanta
This presentation describes the discovery of a novel anti-CTLA-4 Fc multimer that maintains checkpoint blockade activity while simultaneously enhancing the ability to deplete CTLA-4-expressing T regulatory cells with immune-suppressive activity. Such an agent has potential to enhance anti-tumor activity through the dual mechanisms of checkpoint blockade and Treg depletion.
Materials from both sessions will be available for download following their formal presentation at: Momenta Events and Presentations
Momenta is a biotechnology company with a validated innovative scientific platform focused on discovering and developing novel therapeutics to treat rare, immune-mediated diseases. Momenta’s product candidate, M281, is a potentially best-in-class anti-FcRn antibody; M254, is a hypersialylated human immunoglobulin (hsIgG) designed as a high potency alternative to intravenous immunoglobulin (IVIg); and M230 (CSL730), is a potential first-in-class novel recombinant Fc multimer being developed in collaboration with CSL. Momenta also has a focused pipeline of two biosimilar candidates: M923, Momenta’s wholly-owned proposed biosimilar to HUMIRA®, and M710, a proposed biosimilar to EYLEA® being developed in collaboration with Mylan. Momenta’s two FDA-approved complex generic products, enoxaparin sodium injection and Glatopa® (glatiramer acetate injection), are marketed by its collaboration partner, Sandoz.
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Source: Momenta Pharmaceuticals, Inc.